Mitragynine alkaloids as opioid receptor modulators

US10961244B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Andrew Carry Kruegel · New York, US
• Dalibor Sames · New York, US
• Madalee G. Wulf · Ipswich, US
• Jonathan A. Javitch · Dobbs Ferry, US

Key dates

• Filing date: Mar 24, 2017
• Grant date: Mar 30, 2021
• Expiry date: Mar 24, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.