Positive allosteric modulators of the muscarinic acetylcholine receptor M4
US10961253B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Nov 7, 2017 |
| Grant date | Mar 30, 2021 |
| Priority date | — |
| Expiry date | Nov 7, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine and pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine compounds, which may be useful as positive allostenc modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.