N-carboxyanhydride-based-scale synthesis of elamipretide
US10961273B2 · kind B2 · utility
3Cited by
2References
20Claims
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Key dates
| Filing date | Aug 9, 2017 |
| Grant date | Mar 30, 2021 |
| Priority date | — |
| Expiry date | Oct 9, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods of making elamipretide (MTP-131), a peptide compound with therapeutic potential for treating various mitochondrial myopathies. The synthesis of the peptide can be achieved via the use of N-carboxyanhydride-modified amino acid residues, which increases the efficiency of the synthetic process and the purity of the peptide product generated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.