Patent · US Active

Method for synthesizing amanitins

US10961277B2 · kind B2 · utility

0Cited by

2References

9Claims

0Family size

Assignee

Heidelberg Pharma Research GmbH · DE

Inventors

Christian Lutz · Kassel, DE
Werner Simon · Seeheim-Jugenheim, DE
Susanne Werner-Simon · Hüffelsheim, DE
Christoph Müller · Birkenau, DE
Torsten Hechler · Ladenburg, DE
Michael Kulke · Ladenburg, DE

Key dates

Filing date	Aug 6, 2018
Grant date	Mar 30, 2021
Priority date	—
Expiry date	Aug 6, 2038

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4′, 5′ or 7′ of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.