Patent · US Active

DNA logic-gated proximity assembly circuit for biochemical sensing

US10961565B2 · kind B2 · utility

0Cited by
4References
21Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMar 22, 2019
Grant dateMar 30, 2021
Priority date—
Expiry dateMar 22, 2039

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Q1/6825
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

Provided are nucleic acid-based sensors, kits that include such sensors, and methods for making and using such sensors. The sensors permit detection of a broad array of target agents, such as nucleic acids (e.g., DNA and RNA), proteins, cells, and small molecules (e.g., toxins and metals). In some examples, the sensors determine the activity of a protein, such as an enzyme's activity. The assays provide easy-to-read signals for point-of-care diagnosis. The sensors control the conformational switch for recognizing targets and to trigger the subsequent assembly of enzyme/cofactor structures for producing and amplifying signals.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.