TDP-43 in degenerative disease

US10962551B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Philip C. Wong · Timonium, US
• Jonathan Ling · New Brunswick, US

Key dates

• Filing date: Jun 17, 2016
• Grant date: Mar 30, 2021
• Expiry date: Jun 17, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Chimeric proteins comprising an N-terminal domain derived from an N-terminal nucleotide binding domain of TDP-43 and a C-terminal domain derived from a splicing repressor are described. These proteins may be administered to a subject to treat or prevent disease manifesting TDP-43 proteinopathy such as inclusion body myocytosis, amyotrophic lateral sclerosis (ALS), or frontotemporal dementia (FTD).