Functional segregated telodendrimers and nanocarriers and methods of making and using same

US10967003B2 · kind B2 · utility

Assignee

• The Research Foundation for The State University of New York · US

Inventors

• Juntao Luo · Jamesville, US
• Changying Shi · Jamesville, US
• Dandan Guo · Syracuse, US

Key dates

• Filing date: Nov 5, 2019
• Grant date: Apr 6, 2021
• Expiry date: Nov 5, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are multiply functional telodendrimers. The telodendrimers can be used for combination drug delivery. The telodendrimers may have one or more crosslinking groups (e.g., reversible photocrosslinking groups). The telodendrimers can aggregate to form nanocarriers. Cargo such as combinations of drugs, imaging probes, and other materials may be sequestered in the core of the aggregates via non-covalent or covalent interactions with the telodendrimers. Such nanocarriers may be used in drug delivery applications and imaging applications.