Combination therapy for ischemia
US10967041B2 · kind B2 · utility
2Cited by
5References
26Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 1, 2018 |
| Grant date | Apr 6, 2021 |
| Priority date | — |
| Expiry date | Aug 1, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a combination treatment for ischemia conditions in or otherwise affecting the CNS, such as stroke. The treatment involves administration of a PSD-95 inhibitor and performing reperfusion therapy (e.g., by administration of tPA). Administering a PSD-95 inhibitor in combination with reperfusion therapy increases the efficacy of the reperfusion therapy and/or slows the decline in efficacy of reperfusion therapy with time after onset of ischemia thus extending the window in which reperfusion therapy can be administered.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.