Patent · US Active

Cell penetrating conjugates and methods of use thereof

US10967070B2 · kind B2 · utility

2Cited by

6References

8Claims

0Family size

Assignee

City of Hope · US

Inventors

Andreas Herrmann · Stuttgart, DE
Hua Yu · Glendora, US
Piotr Marek Swiderski · San Dimas, US
John E. Shively · Arcadia, US
Lin Li · 安丰镇, CN

Key dates

Filing date	Feb 29, 2016
Grant date	Apr 6, 2021
Priority date	—
Expiry date	Feb 29, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/3513
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.