Patent · US Active

Crystalline solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide and methods of their synthesis

US10968192B2 · kind B2 · utility

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3References

5Claims

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Assignee

LEXICON PHARMACEUTICALS, INC. · US

Inventors

Mark S. Bednarz · Yardley, US
Kuangchu DAI · Changzhou City, CN
Jeffrey Eckert · Hazlet, US
Ngiap-Kie Lim · South San Francisco, US
Lauren Elizabeth SIROIS · San Francisco, US
Wenxue Wu · Princeton Junction, US
Matthew Mangzhu Zhao · Edison, US

Key dates

Filing date	Sep 23, 2019
Grant date	Apr 6, 2021
Priority date	—
Expiry date	Sep 23, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Methods of preparing, and solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide, and salts, solvates and cocrystals thereof, are disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.