Salts of an LSD1 inhibitor and processes for preparing the same

US10968200B2 · kind B2 · utility

Assignee

• Incyte Corporation · US

Inventors

• Zhongjiang Jia · Kennett Square, US
• Wayne Han · West Chester, US
• Yongchun Pan · Wilmington, US
• Timothy P. Martin · Noblesville, US
• Jiacheng Zhou · Shanghai, CN
• Qun Li · Beijing, CN

Key dates

• Filing date: Aug 29, 2019
• Grant date: Apr 6, 2021
• Expiry date: Aug 29, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to processes and intermediates for preparing 3-(cyanomethyl)-3-(4-{[(1R,2S)-2-phenylcyclopropyl]amino}piperidin-1-yl)azetidine-1-sulfonamide, and salts and solid forms thereof, which selectively modulate demethylase. Particular embodiments contemplate compounds and disease indications amenable to treatment by modulation of lysine specific demethylase-1 (LSD1).