Pyrido five-element aromatic ring compound, preparation method therefor and use thereof

US10968215B2 · kind B2 · utility

Assignees

• SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. · CN
• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Xuxing Chen · Shanghai, CN
• Meiyu Geng · Shanghai, CN
• Lei Jiang · Shanghai, CN
• Yi Chen · Shanghai, CN
• Jianhua Cao · Laishui, CN
• Qingyun Jiang · Shanghai, CN
• Qianqian Shen · Shanghai, CN
• Jian Ding · Shanghai, CN
• Yucai Yao · Shanghai, CN
• Zhao Zhao · Boston, US
• Yuanfang Xiong · Shanghai, CN

Key dates

• Filing date: Sep 6, 2017
• Grant date: Apr 6, 2021
• Expiry date: Sep 6, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a pyrido five-element aromatic ring compound, and a preparation method therefor and a use thereof. The compound provided in the present invention has an inhibitory effect on wild-type and/or mutant EZH2, and is well positioned to become a novel anti-tumor drug or a drug for the treatment of autoimmune diseases.