Recombinant Vibrio natriegens organisms having a modified outer membrane
US10968496B2 · kind B2 · utility
1Cited by
1References
17Claims
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Assignee
Inventors
Key dates
| Filing date | Oct 8, 2018 |
| Grant date | Apr 6, 2021 |
| Priority date | — |
| Expiry date | Oct 8, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides engineered Vibrio sp. organisms that comprise a genetic modification to either or both of the lpxL and/or lpxM genes. The organisms score substantially lower in an in vitro endotoxin assay versus the unmodified or wild type organism. The organisms preserve substantially the growth rate of the corresponding unmodified organisms. The organisms can also have an exogenous nucleic acid cloned in the organism, or an exogenous nucleic acid encoding a protein, polypeptide, or peptide expressed by the organism, and optionally secreted from the organism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.