System and method for deforming and analyzing particles

US10969327B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Dino Di Carlo · Los Angeles, US
• Daniel R. Gossett · Los Angeles, US
• Henry T.K. Tse · San Francisco, US
• Aram Chung · Seoul, KR

Key dates

• Filing date: Apr 3, 2019
• Grant date: Apr 6, 2021
• Expiry date: Apr 3, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T7/0016
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet. The fluidic pathway includes a delivery region configured to receive the plurality of particles from the inlet and focus the plurality of particles from a random distribution to a focused state, a deformation region defining an intersection located downstream of the delivery region and coupled to the outlet, and wherein the deformation region is configured to receive the plurality of particles from the delivery region and to transmit each particle in the plurality of particles into the intersection from a single direction, a first branch fluidly coupled to the deformation region and configured to transmit a first flow into the intersection, and a second branch fluidly coupled to the deformation region and configured to transmit a second flow, substantially opposing the first flow, into the intersection, wherein the first flow and the second flow are configured to induce extension of one or more particles in the plurality of particles.