Method to monitor and quantify interphase nuclear envelope rupture events
US10969389B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Feb 17, 2017 |
| Grant date | Apr 6, 2021 |
| Priority date | — |
| Expiry date | Feb 17, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/9125
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides an in vitro method for monitoring interphase nuclear envelope rupture events in a eukaryotic cell or screening or identifying compound capable of increasing or decreasing the intensity and/or frequency of interphase nuclear envelope rupture events in a eukaryotic cell. These methods relate on a protein having a cytosolic non-nuclear localization in interphase and a non-sequence specific DNA binding activity. Interphase nuclear envelope rupture events are characterized by the presence of the protein of the invention in the nucleus of the eukaryotic cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.