Pharmaceutical composition for preventing and treating cancer, containing CYB5R3 gene or protein as active ingredient
US10973884B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Mar 31, 2016 |
| Grant date | Apr 13, 2021 |
| Priority date | — |
| Expiry date | Jul 8, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/90209
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a pharmaceutical composition for treating cancer, containing cytochrome b5 reductase 3 (CYB5R3) protein as an active ingredient. Over-expression of CYB5R3 in cancer cells results in significant reduction of hypoxia-inducible factor-1α (HIF-1α) expression, which leads inhibition of cancer cells growth in vitro and in vivo. Thus, the CYB5R3 gene or protein of the present invention can be useful as an active ingredient of a pharmaceutical composition for treating cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.