Patent · US Active

Benzothiazepine compounds and their use as bile acid modulators

US10975045B2 · kind B2 · utility

18Cited by

60References

9Claims

0Family size

Assignee

Aibireo AB · SE

Inventors

Per-Göran Gillberg · Timrå, SE
Jan Mattsson · Gothenburg, SE
Ingemar Starke · Gothenburg, SE
Santosh S. Kulkarni · Kanchinakote, IN

Key dates

Filing date	Feb 28, 2020
Grant date	Apr 13, 2021
Priority date	—
Expiry date	Feb 28, 2040

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P1/16
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to 1,5-benzothiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.