Patent · US Active

Catalyst-free surface functionalization and polymer grafting

US10975210B2 · kind B2 · utility

1Cited by

46References

18Claims

0Family size

Assignee

Illumina, Inc. · US

Inventors

Lorenzo Berti · San Diego, US
Andrew A. Brown · Cambridge, GB
Wayne N. George · London, GB

Key dates

Filing date	May 24, 2018
Grant date	Apr 13, 2021
Priority date	—
Expiry date	Nov 9, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08J2335/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present application relates to a method for preparing a functionalized surface and the use in DNA sequencing and other diagnostic applications. A substrate with a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene can be used for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. In some embodiments, the silane or silane derivative contains optionally substituted norbornene or norbornene derivatives.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.