Patent · US Active

Mass spectrometric quantitation

US10976321B2 · kind B2 · utility

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1References

19Claims

0Family size

Assignee

ELECTROPHORETICS LIMITED · GB

Inventors

Peter Schulz-Knappe · Hemmingen, DE
Ian Hugo Pike · London, GB
Karsten Kuhn · Dortmund, DE

Key dates

Filing date	Jan 23, 2017
Grant date	Apr 13, 2021
Priority date	—
Expiry date	Feb 19, 2038

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10T436/105831
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Provided is a method of assaying for an analyte, including combining a test sample having the analyte, with a calibration sample having at least two different aliquots of the analyte, each aliquot having a different known quantity of the analyte. The test sample and each aliquot are differentially labeled with one or more isobaric mass labels each with a mass spectrometrically distinct mass marker group, such that the test sample and each aliquot of the calibration sample can be distinguished by mass spectrometry. The method further includes determining by mass spectrometry the quantity of analyte in the test sample and in each aliquot, and calibrating the quantity of analyte in the test sample against known and determined quantities of analytes in the aliquots.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.