Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using electrodes with microvoltammetry
US10980460B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 15, 2017 |
| Grant date | Apr 20, 2021 |
| Priority date | — |
| Expiry date | Oct 5, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/302
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention also provides methods of differentiating white matter from gray matter. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using sensors. The invention further provides methods of measuring the neurotoxicity of a material by comparing microvoltammograms of a neural tissue in the presence and absence of the material using the inventive sensors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.