Crystalline salts of naloxone and naltrexone
US10980799B2 · kind B2 · utility
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20Claims
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Inventors
Key dates
| Filing date | Sep 26, 2016 |
| Grant date | Apr 20, 2021 |
| Priority date | — |
| Expiry date | Nov 13, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to crystalline salts of naloxone and of naltrexone and their use as opioid antagonists. The crystalline salts of the invention include naloxone saccharinate, naltrexone succinate and a methanol solvate of naltrexone succinate. A drug-in-adhesive transdermal patch containing the opioid analgesic fentanyl or an analog thereof and a crystalline salts of naloxone or naltrexone is disclosed. Also disclosed is a method of treating pain, such as acute, chronic or intermittent pain, by applying a drug-in-adhesive transdermal patch of the invention to the skin of a patient in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.