Cytotoxic immunostimulating particles and uses thereof
US10980875B2 · kind B2 · utility
2Cited by
1References
13Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 20, 2016 |
| Grant date | Apr 20, 2021 |
| Priority date | — |
| Expiry date | Mar 15, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/572
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to particles comprising RNA, in which the RNA is associated with a cationic polymer or lipid or with both a cationic polymer and lipid, wherein the RNA comprises a cytotoxic nucleotide or cytotoxic nucleotide analog and/or the RNA is covalently attached to a cytotoxin, pharmaceutical compositions containing said particles and pharmaceutical uses of the particles and pharmaceutical compositions. The particles of the present invention are particularly useful as an immunostimulating medicament capable to block proliferation or induce death in dividing cells such as tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.