Patent · US Active

Nicotinic acid or isonicotinic acid compound and use thereof

US10981873B2 · kind B2 · utility

0Cited by

1References

4Claims

0Family size

Assignee

Academy of Military Medical Sciences · CN

Inventors

Hui Wang · Alishan, TW
Tao Li · San Diego, US
Zhenyuan Miao · Beijing, CN
Jianxin Wang · Zhejiang, CN
Deyan Luo · Saranac Lake, US
Jie-Len Huang · Hsinchu, TW
Chunlin Zhuang · Shanghai, CN
Yuelin Wu · Beijing, CN

Key dates

Filing date	Sep 8, 2017
Grant date	Apr 20, 2021
Priority date	—
Expiry date	Sep 8, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D213/79
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are a nicotinic acid or isonicotinic acid compound and a use thereof. The compound is the compound shown in Formula I, or a pharmaceutically acceptable salt, ester or solvate thereof. Efficacy tests demonstrate that the nicotinic acid compound can inhibit botulinum toxin endopeptidase activity in vitro, and has a significant protective effect on mice poisoned with botulinum toxin. On this basis, the compound may be used to prepare a drug preventing and/or treating botulinum toxin exposure and/or poisoning.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.