Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
US10981929B2 · kind B2 · utility
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Key dates
| Filing date | Jun 30, 2017 |
| Grant date | Apr 20, 2021 |
| Priority date | — |
| Expiry date | Jun 30, 2037 |
Classification
- Technology area (CPC —)General
Abstract
The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.