Peptides having antimicrobial activity and new enzyme capable of converting L-configured residue in D-configured amino acid in a peptide

US10981957B2 · kind B2 · utility

Assignee

• INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION L'ENVIRONNEMENT · FR

Inventors

• ALHOSNA BENJDIA · Limeil-Brévannes, FR
• Alain Guillot · Les Ulis, FR
• Olivier Berteau · Vélizy-Villacoublay, FR

Key dates

• Filing date: Dec 1, 2016
• Grant date: Apr 20, 2021
• Expiry date: Dec 1, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a new class of peptides having antibacterial activity and presenting D-amino acids and their uses. It also relates to a new enzyme presenting a peptide epimerase activity in vitro and in vivo, thereby being useful for modifying peptides in order to change the amino acid configuration from L to D.