Patent · US Active

Detection of a posttranslationally modified polypeptide by a bivalent binding agent

US10982007B2 · kind B2 · utility

0Cited by

16References

3Claims

0Family size

Assignee

Roche Diagnostics Operations, Inc. · US

Inventors

Michael Gerg · Munich, DE
Dieter Heindl · Munich, DE
Christian Klein · Iffeldorf, DE
Alfred Mertens · Schriesheim, DE
Volker Schmid · Penzberg, DE
Michael Schraeml · Penzberg, DE
Monika Soukupova · Wessobrunn, DE
Michael Tacke · Munich, DE

Key dates

Filing date	Mar 21, 2017
Grant date	Apr 20, 2021
Priority date	—
Expiry date	Aug 31, 2037

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/531
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

A bivalent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bivalent binding agent, and for use of the disclosed bivalent binding agent in histological staining procedures.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.