Beta-lactamase variants
US10982205B2 · kind B2 · utility
1Cited by
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20Claims
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Key dates
| Filing date | Feb 22, 2017 |
| Grant date | Apr 20, 2021 |
| Priority date | — |
| Expiry date | Jun 24, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a Verona integron-encoded metallo-β-lactamase (VIM-2) variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.