K-RAS gene expression-suppressing siRNA, precursor of same, and applications thereof
US10982213B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | May 5, 2017 |
| Grant date | Apr 20, 2021 |
| Priority date | — |
| Expiry date | May 5, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses an siRNA that inhibits K-RAS gene expression, and the precursor sequences and applications thereof. The K-RAS siRNA and its precursor sequences provided by the present invention can efficiently inhibit the expression of the K-RAS gene, and in vivo experiments have shown that the K-RAS siRNA has a certain inhibitory effect on tumours highly expressing K-RAS. The precursor of the siRNA of the invention and its vector can form a stable siRNA that functions in a host.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.