Pharmaceutical compositions of water soluble peptides with poor solubility in isotonic conditions and methods for their use
US10987402B2 · kind B2 · utility
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10References
19Claims
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Key dates
| Filing date | Jul 16, 2019 |
| Grant date | Apr 27, 2021 |
| Priority date | — |
| Expiry date | Jul 16, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/36
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions comprising water soluble peptides with poor solubility in isotonic solutions which exhibit enhanced bioavailability with reduced adverse effects including injection site reactions. Methods are also disclosed for using such compositions for the treatment of diseases including, but not limited to, cancer, type 2 diabetes, acromegaly, metabolic disorders, endocrine disorders, exocrine tumors, and hormone-related tumors. Methods to reduce adverse injection site reactions and improve bioavailability are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.