Reagents and methods for identifying, enriching, and/or expanding antigen-specific T cells

US10987412B2 · kind B2 · utility

Assignee

• The John Hopkins University · US

Inventors

• Jonathan Schneck · Silver Spring, US
• Karlo Perica · Baltimore, US
• Joan Glick Bieler · Silver Spring, US
• Mathias Oelke · Parkville, US

Key dates

• Filing date: Sep 17, 2015
• Grant date: Apr 27, 2021
• Expiry date: Jan 13, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/70539
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining T cell reactivity with a library of candidate peptide antigens.