Patent · US Active

Methods for improved production of vitamins D2 and D3

US10988443B2 · kind B2 · utility

0Cited by
6References
7Claims
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Assignee

Inventor

Key dates

Filing dateJul 1, 2019
Grant dateApr 27, 2021
Priority date
Expiry dateJul 1, 2039

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07C2602/24
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

It is an object of the present invention to provide methods for producing vitamin D that gives improved yields and reduced side product contamination. In various aspects, these methods provide for production of vitamin-D2 using ergosterol as provitamin D2 or a dihydroxy derivative thereof as a starting material, or production of vitamin-D3 using 7-dehydrocholesterol as provitamin D3 or a dihydroxy derivative thereof as the starting material. The methods described herein comprise irradiating the starting material in a solution including an organic or inorganic base with light in the wavelength range 245-360 nanometers (nm) to obtain a product containing pre-vitamin-D2 or pre-vitamin-D3, and heating the product to convert the resulting pre-vitamin-D2 or pre-vitamin-D3 to vitamin D2 or vitamin D3. In various embodiments, these methods further comprise recovering vitamin D2 or vitamin D3 from this reaction as a purified product.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.