Patent · US Active

Methods for obtaining pluripotent adult olfactory stem cells from an olfactory mucosa tissue

US10988733B2 · kind B2 · utility

1Cited by

3References

3Claims

0Family size

Assignee

China Medical University · TW

Inventors

Woei-Cherng Shyu · Taipei, TW
Chung-Y. Hsu · Taichung, TW
Der-Yang Cho · Taichung, TW
Chen-Huan Lin · Hangzhou City, CN
Wei Lee · Taipei, TW
San-Yuan Chen · Hsinchu, TW
Long-Bin JENG · Taichung, TW
Chang-Hai Tsai · Taichung, TW

Key dates

Filing date	May 19, 2020
Grant date	Apr 27, 2021
Priority date	—
Expiry date	May 19, 2040

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/5073
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

A method for obtaining a plurality of pluripotent adult olfactory stem cells (APOSCs) includes isolating the APOSCs, culturing the isolated APOSCs in a sphere culture medium, and collecting the cultured APOSCs that express Bmi-1 (B-lymphoma moloney murine leukemia virus insertion region-1), Oct-4 (Octamer-binding transcription factor 4), Sox-2 (Sex-determining region Y (SRY)-box 2), Nanog, SSEA-4 (Stage-specific embryonic antigen-4), ki67, c-Myc, KLF-4 (Kruppel Like Factor 4), K14 (Cytokeratin 14) and ICAM-1 (Intercellular Adhesion Molecule 1).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.