Cardiac tissues containing semiconductor nanomaterials and methods of preparing and using the same

US10988735B2 · kind B2 · utility

Assignees

• CLEMSON UNIVERSITY RESEARCH FOUNDATION · US
• MUSC Foundation for Research Development · US
• THE UNIVERSITY OF CHICAGO · US

Inventors

• Ying Mei · Cambridge, US
• Tan Yu · Charleston, US
• Dylan Richards · Chicago, US
• Donald R. Menick · Mount Pleasant, US
• Bozhi Tian · Cambridge, US

Key dates

• Filing date: Jan 15, 2016
• Grant date: Apr 27, 2021
• Expiry date: Feb 11, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are tissues containing semiconductor nanomaterials. In some embodiments, the tissues include vascular cells, cardiomyocytes, and/or cardiac fibroblasts. The tissue may be scaffold-free. In some embodiments, the tissue includes an electrically conductive network. The tissue may exhibit synchronized electrical signal propagation within the tissue. In some embodiments, the tissue exhibits increased functional assembly of cardiac cells and/or increased cardiac specific functions compared to a cardiac tissue prepared using a conventional tissue culture method. Methods of preparing and using such tissues are also described herein.