Molecular imaging of biological samples with sub-cellular spatial resolution and high sensitivity
US10991563B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 27, 2019 |
| Grant date | Apr 27, 2021 |
| Priority date | — |
| Expiry date | Aug 27, 2039 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/005
- WIPO fieldElectrical machinery, apparatus, energy
- WIPO sectorElectrical engineering
Abstract
An apparatus for molecular imaging of biological samples includes a first optical port configured to receive a first pulsed optical beam that is directed in an optical path along an optical axis. A transparent target that include a first surface having an electrically conductive surface that supports a biological sample under analysis and a second surface is positioned in the optical path along the optical axis. A moveable target mount is configured to translate the transparent target to a plurality of predetermined locations. A first optical focusing element is configured to focus the first pulsed optical beam to a first predetermined diameter at the first surface of the transparent target. A second optical port is configured to receive a second pulsed optical beam that is directed in a second optical path along the optical axis. A second optical focusing element is configured to focus the second pulsed optical beam to a second predetermined diameter at the electrically conductive surface on the transparent target. A TOF mass spectrometer comprising an ion accelerator having a central axis that is substantially coaxial with the optic axis so that ions generated by the first and se…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.