Peptides and combination of peptides for use in immunotherapy against leukemias and other cancers

US10993963B2 · kind B2 · utility

Assignee

• Immatics Biotechnologies GmbH · DE

Inventors

• Juliane Walz · Lörrach, DE
• Daniel Johannes KOWALEWSKI · Rötteln, DE
• Markus LOEFFLER · Herrenberg, DE
• Moreno DI MARCO · Lörrach, DE
• Nico TRAUTWEIN · Stuttgart, DE
• Annika NELDE · Rötteln, DE
• Stefan Stevanovic · Lörrach, DE
• Hans-Georg Rammensee · Lörrach, DE
• Sebastian HAEN · Lörrach, DE

Key dates

• Filing date: Feb 18, 2020
• Grant date: May 4, 2021
• Expiry date: Feb 18, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.