Methods for enhancing and modulating reversible and irreversible electroporation lesions by manipulating pulse waveforms
US10994133B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 4, 2020 |
| Grant date | May 4, 2021 |
| Priority date | — |
| Expiry date | Feb 4, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2018/126
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A ratio of reversible electroporation and irreversible electroporation may be controlled by selecting a symmetric waveform or asymmetric waveform to either minimize or enhance irreversible effects on cells in the target tissue. Combined reversible and irreversible electroporation includes inserting one or more therapeutic electrodes into a target tissue, introducing an electroporation compound into the target tissue, selecting a pulse waveform that is either 1) asymmetric bipolar that has positive and negative pulses with different durations, or 2) symmetric bipolar that has positive and negative pulses with the same duration, and delivering to the target tissue a series of electrical pulses having the selected pulse waveform.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.