Patent · US Active

Site-specific glycoengineering of targeting moieties

US10995148B2 · kind B2 · utility

6Cited by

36References

39Claims

0Family size

Assignee

Genzyme Corporation · US

Inventors

Luis Z. Avila · Arlington, US
Clark Pan · Sudbury, US
Huawei Qiu · Westborough, US
Qun Zhou · Ashland, US

Key dates

Filing date	Mar 18, 2015
Grant date	May 4, 2021
Priority date	—
Expiry date	Jan 18, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/92
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.