Patent · US Active

1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase

US11000525B2 · kind B2 · utility

0Cited by

3References

2Claims

0Family size

Assignee

ASTRAZENECA AB · SE

Inventors

Tord Inghardt · Gately Drive, SE
Petra Johannesson · Mölndal, SE
Ulrik Jurva · Timrå, SE
Erik MICHAELSSON · Timrå, SE
Eva-Lotte Lindstedt-Alstermark · Mölndal, SE
Nicholas Tomkinson · Macclesfield, GB
Jeffrey Paul Stonehouse · Coalville, GB
Li Gan · Ebikon, CH

Key dates

Filing date	Jun 15, 2018
Grant date	May 11, 2021
Priority date	—
Expiry date	Jun 15, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D487/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

There are disclosed certain 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one compounds of formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.