Engineering gut commensal bacteria to express heterologous proteins in their outer membrane vesicles (OMVs) for delivery to the GI-tract
US11000581B2 · kind B2 · utility
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Key dates
| Filing date | Apr 28, 2017 |
| Grant date | May 11, 2021 |
| Priority date | — |
| Expiry date | Apr 28, 2037 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.