Determining a quantity of an analyte in a blood sample

US11000848B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Christoph Boehm · Viernheim, DE
• Thomas Dolbinow · Dresden, DE
• Sabrina Adler · Mannheim, DE
• Erik Beiersdorf · Hemsbach, DE
• Domenik Wensorra · Mannheim, DE
• Thorsten Brueckner · Schriesheim, DE
• Thomas Fischer · Wiesloch, DE
• Eloisa Lopez-Calle · Ludwigshafen, DE
• Sascha Lutz · Neustadt, DE
• Josef Roedl · Mutterstadt, DE
• Juergen Spinke · Lorsch, DE
• Pamela Espindola · Mannheim, DE
• Thomas Manuel Keller · Schifferstadt, DE

Key dates

• Filing date: May 17, 2018
• Grant date: May 11, 2021
• Expiry date: Mar 19, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2035/1032
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.