Bi-layer multi-well cell culture platform

US11001796B2 · kind B2 · utility

Assignee

• The Charles Stark Draper Laboratory, Inc. · US

Inventors

• Jonathan R. Coppeta · Windham, US
• Joseph L. Charest · Cambridge, US
• Else M. Vedula · Brookline, US
• Jeffrey T. Borenstein · Holliston, US
• Abigail June Spencer · Boston, US
• Brett Isenberg · Newton, US

Key dates

• Filing date: Nov 21, 2017
• Grant date: May 11, 2021
• Expiry date: Jul 14, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2535/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The methods and systems described herein provide a cell culture platform with an array of tissue modeling environments and dynamic control of fluid flow. The cell culture platform includes an array of wells that are fluidically coupled by microchannel structures. The dynamically controlled flow of fluid interacts with cells grown within the microchannels.