Patent · US Active

High fidelity restriction endonucleases

US11001818B2 · kind B2 · utility

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4Claims

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Inventors

Zhenyu Zhu · Lynnfield, US
Aine Quimby · Newburyport, US
Shengxi Guan · Stoneham, US
Dapeng Sun · Lexington, US
Yishu Huang · Shanghai, CN
Xuhui Lai · Shanghai, CN
Siu-hong Chan · Ipswich, US
Xianghui Li · Shanghai, CN
Shuang-Yong Xu · Lexington, US
Chunhua Zhang · Longbeilingcun, CN

Key dates

Filing date	Mar 15, 2019
Grant date	May 11, 2021
Priority date	—
Expiry date	Mar 15, 2039

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/922
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.