Endos mutant enzyme
US11001819B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Jul 15, 2016 |
| Grant date | May 11, 2021 |
| Priority date | — |
| Expiry date | Jan 24, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/41
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides an EndoS mutant enzyme having an amino acid sequence of EndoS D233Q and further having a particular additional mutation and exhibiting a reduced hydrolysis activity, in comparison with the activity of EndoS D233Q, to an N-linked sugar chain (N297-linked sugar chain) linked to Asn at position 297 in IgG and a gene encoding the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.