Methods for modeling hepatic inflammation

US11004543B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Joyeeta Dutta-Moscato · Pittsburgh, US
• Liang-I Kang · Pittsburgh, US
• Qi Mi · Pittsburgh, US
• Kari Nejak-Bowen · Wexford, US
• Yoram Vodovotz · Dorpsstraat, US

Key dates

• Filing date: Jul 29, 2016
• Grant date: May 11, 2021
• Expiry date: Dec 4, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G16B50/00
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Provided herein are in silico methods of modeling hepatic inflammation, fibrosis/cirrhosis, and cancer. The models are computer-implemented agent-based models and are useful in determining patient prognoses in hepatic conditions, including viral infections, damage, inflammation, and cancer. The modeling system also is useful in modeling the effects of active agents on normal hepatic tissue or hepatic tissue perturbed by inflammation, infection, damage, fibrosis/cirrhosis, and cancer.