Implant and coating to reduce osteolysis
US11007303B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 6, 2016 |
| Grant date | May 18, 2021 |
| Priority date | — |
| Expiry date | Oct 6, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/24
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coaling. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.