FGFR4 inhibitor and preparation method and use thereof

US11008292B2 · kind B2 · utility

Inventors

• Zhengxia Chen · Shanghai, CN
• Chaofeng Long · Tangxia, CN
• Yang Zhang · San Diego, US
• Xiaoxin Chen · Cupertino, US
• Yikai Wang · Shanghai, CN
• Meibi Dai · Shanghai, CN
• Zhuowei Liu · 流花街道, CN
• Haixia ZHAO · Shanghai, CN
• Xing Liu · Hefei, CN
• Guoping HU · Shanghai, CN
• Jian Li · Shanghai, CN
• Shuhui CHEN · Shanghai, CN

Key dates

• Filing date: Nov 17, 2017
• Grant date: May 18, 2021
• Expiry date: Nov 17, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a class of compounds as shown in formula (I) as FGFR4 inhibitors, and pharmaceutically acceptable salts thereof, preparation methods therefor and the use thereof in the preparation of drugs for treating FGFR4-related diseases.