Patent · US Active

Method of synthesizing (1S,12bS) lactam ester compound

US11008322B1 · kind B1 · utility

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10Claims

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Assignee

Sichuan University · CN

Inventors

Fener CHEN · Shanghai, CN
PEI-CHONG TANG · Taipei, TW
Wen Zhang · Lexington, US
Lin Dong · Sunnyvale, US
Youcai Xiao · Sichuan, CN

Key dates

Filing date	Apr 7, 2020
Grant date	May 18, 2021
Priority date	—
Expiry date	Apr 7, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/14
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed herein is a method of synthesizing a (1S,12bS) lactam ester compound, including: subjecting a dihydrocarboline diester compound of formula (II) to asymmetric hydrogenation and lactamization in an organic solvent in the presence of an iridium catalyst precursor, a chiral diphosphine ligand and a halogen-containing reagent under hydrogen atmosphere to produce the (1S,12bS) lactam ester compound of formula (I), as shown in the following reaction scheme, where R1, R2 and R3 are defined in the same manner with the specification.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.