Trifunctional T cell-antigen coupler and methods and uses thereof
US11008376B2 · kind B2 · utility
9Cited by
3References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 6, 2020 |
| Grant date | May 18, 2021 |
| Priority date | — |
| Expiry date | May 6, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.