Antibodies against IL-7R alpha subunit and uses thereof

US11008395B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Aaron P. YAMNIUK · Lawrenceville, US
• Scott Ronald Brodeur · New Hope, US
• Ekaterina Deyanova · Lawrenceville, US
• Richard Y. Huang · Princeton, US
• Yun Wang · New Taipei, TW
• Alfred Robert Langish · Princeton, US
• Guodong Chen · East Brunswick Township, US
• Stephen M. Carl · Howell, US
• Hong Shen · Shanghai, CN
• Achal Pashine · Mahwah, US
• Lin Hui Su · Somerville, US

Key dates

• Filing date: Jan 21, 2020
• Grant date: May 18, 2021
• Expiry date: Jan 21, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.