Genetically-modified immune cells comprising a microRNA-adapted shRNA (shRNAmiR)
US11008548B2 · kind B2 · utility
2Cited by
6References
3Claims
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Key dates
| Filing date | Jun 22, 2020 |
| Grant date | May 18, 2021 |
| Priority date | — |
| Expiry date | Jun 22, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention encompasses genetically-modified immune cells (and populations thereof) expressing a microRNA-adapted shRNA (shRNAmiR) that reduces the expression of a target endogenous protein. Methods for reducing the expression of an endogenous protein in an immune cell are also provided wherein the method comprises introducing a shRNAmiR that targets the endogenous protein. Using shRNAmiRs for knocking down the expression of a target protein allows for stable knockdown of expression of endogenous proteins in immune cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.